abstract：OBJECTIVE:This review of heparin-induced thrombocytopenia (HIT), the most frequent and dangerous side effect of heparin exposure, covers the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of this disease syndrome. DATA SOURCES AND STUDY SELECTION:Current consensus of opinion is given ba...

journal_title：Archives of pathology & laboratory medicine

authors： Fabris F,Ahmad S,Cella G,Jeske WP,Walenga JM,Fareed J

更新日期：2000-11-01 00:00:00

abstract：:Primary dural lymphoma is rare, and few of the small number of cases reported to date have been classified using immunohistochemical techniques. To our knowledge, we report the first case of T-cell-rich B-cell lymphoma (diffuse mixed small cell and large cell) presenting as a solitary intracranial dural mass. Cytologi...

journal_title：Archives of pathology & laboratory medicine

authors： Amaker BH,Ghatak NR,Jebraili SA,Ferreira-Gonzalez A,Kornstein MJ

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:The pathogenesis of appendicitis remains poorly understood. However, there is increasing evidence of involvement of the enteric nervous system in immune regulation and in inflammatory responses. This study was set up to characterize the status of the enteric nervous system in normal and in inflamed appendixes...

journal_title：Archives of pathology & laboratory medicine

authors： Xiong S,Puri P,Nemeth L,O'Briain DS,Reen DJ

更新日期：2000-10-01 00:00:00

abstract：CONTEXT:Enterocytozoon bieneusi is the most frequent microsporidian parasite of human patients with acquired immunodeficiency syndrome and is a significant cause of diarrhea and wasting. Recently, this organism has also been recognized as a spontaneous infection of several species of captive macaques. As in humans, E b...

journal_title：Archives of pathology & laboratory medicine

authors： Chalifoux LV,Carville A,Pauley D,Thompson B,Lackner AA,Mansfield KG

更新日期：2000-10-01 00:00:00

abstract：:We describe a case of ovarian adenoid cystic carcinoma (ACC) of the left ovary in a 23-year-old woman. The tumor had the typical cribriform pattern of ACC, lacked any component of surface epithelial carcinoma, and showed myoepithelial differentiation. The features of salivary gland-type tumor seen in this case are unu...

journal_title：Archives of pathology & laboratory medicine

authors： Zámecník M,Michal M,Curík R

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:The major biochemical characteristic of Dupuytren disease is the progressive and irreversible deposition of excess fibrous collagen characterized by an enhanced type III collagen proportion. OBJECTIVE:To investigate the influence of changes of the collagen spectrum on the biophysical properties of the palma...

journal_title：Archives of pathology & laboratory medicine

authors： Melling M,Karimian-Teherani D,Mostler S,Behnam M,Sobal G,Menzel EJ

更新日期：2000-09-01 00:00:00

abstract：CONTEXT:The differentiation between iron deficiency and a thalassemia syndrome is an important consideration in the investigation of microcytic anemia. OBJECTIVE:An established statistical method was used to demonstrate the importance of considering ethnic background in combination with mean cell volume (MCV) in the i...

journal_title：Archives of pathology & laboratory medicine

authors： Kiss TL,Ali MA,Levine M,Lafferty JD

更新日期：2000-09-01 00:00:00

abstract：:In this report, we describe a highly unusual case of glandular malignant peripheral nerve sheath tumor presenting as a neck mass in a previously healthy 29-year-old man. Grossly, the tumor was found to arise from a swollen peripheral nerve trunk. The tumor was largely composed of spindle cells that demonstrated marked...

journal_title：Archives of pathology & laboratory medicine

authors： Nagasaka T,Lai R,Sone M,Nakashima T,Nakashima N

更新日期：2000-09-01 00:00:00

abstract：CONTEXT:Recent advances in laboratory testing technology have resulted in a rapidly increasing number of test systems targeted for physician office, point-of-care, and home health care settings. With enhanced error detection mechanisms and unitized reagents, these new systems simplify the testing process and the assess...

journal_title：Archives of pathology & laboratory medicine

authors： LaBeau KM,Simon M,Steindel SJ

更新日期：2000-08-01 00:00:00

abstract：CONTEXT:Hyalinizing spindle cell tumor with giant rosettes is a recently described biphasic neoplasm of soft tissues that shares mesenchymal and neuroendocrine features. Its morphologic structure is distinctive, with the presence of hyalinized paucicellular foci that are termed rosettes. The cells around the latter dis...

journal_title：Archives of pathology & laboratory medicine

authors： Bejarano PA,Padhya TA,Smith R,Blough R,Devitt JJ,Gluckman JL

更新日期：2000-08-01 00:00:00

abstract：:Rectal carcinoma is uncommonly associated with systemic metastases in the absence of liver metastases, reflecting the predilection for spread via the portal system. Occasionally, isolated lung metastases are seen, which are usually attributed to spread via the portosystemic anastomoses in the distal rectum. However, m...

journal_title：Archives of pathology & laboratory medicine

authors： Mathew P,Fleming D,Adegboyega PA

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVES:To identify resources and summarize important issues in anatomic and clinical pathology training and to assist the pathology resident candidate in evaluating potential training programs. DATA SOURCES:Published guides for medical residency applicants, recent literature discussing pathology education, and Wor...

journal_title：Archives of pathology & laboratory medicine

authors： Yorke RF

更新日期：2000-06-01 00:00:00

abstract：:Most mesenchymal tumors of the gastrointestinal tract are now referred to as gastrointestinal stromal tumors (GISTs). The tumors differ from ordinary leiomyomas and schwannomas in several respects: the GISTs typically express c-kit protein (CD117) and CD34, 30% to 50% of them are (often focally) positive for alpha-smo...

journal_title：Archives of pathology & laboratory medicine

authors： Lasota J,Carlson JA,Miettinen M

更新日期：2000-06-01 00:00:00

abstract：:Human anti-mouse antibodies (HAMA) are human immunoglobulins with specificity for mouse immunoglobulins. This topic currently is of interest because of the increased use of monoclonal mouse antibodies as diagnostic reagents both for in vitro laboratory measurements and for in vivo imaging studies. Monoclonal mouse ant...

journal_title：Archives of pathology & laboratory medicine

authors： Klee GG

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Primary liposarcomas of the pleura are extremely rare malignancies, and relatively few reports appear in the world literature. DESIGN:We compiled a small series of 4 cases of primary pleural liposarcoma from the files of the Armed Forces Institute of Pathology (Washington, DC) and compared the histopatholog...

journal_title：Archives of pathology & laboratory medicine

authors： Okby NT,Travis WD

更新日期：2000-05-01 00:00:00

abstract：:Lymphoepithelioma-like carcinomas have been reported outside the nasopharynx in many sites, including the uterine cervix. The association with the Epstein-Barr virus in the latter site is still controversial. To date, Epstein-Barr virus genome has only been demonstrated in Asian patients. We report a case of lymphoepi...

journal_title：Archives of pathology & laboratory medicine

authors： López-Ríos F,Miguel PS,Bellas C,Ballestín C,Hernández L

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To study the immunoreactivity profile of the neuron-associated class III beta-tubulin isotype (beta III) in epithelial lung tumors. DESIGN:One hundred four formalin-fixed, paraffin-embedded primary and metastatic lung cancer specimens were immunostained with an anti-beta III mouse monoclonal antibody (TuJ1) ...

journal_title：Archives of pathology & laboratory medicine

authors： Katsetos CD,Kontogeorgos G,Geddes JF,Herman MM,Tsimara-Papastamatiou H,Yu Y,Sakkas LI,Tsokos M,Patchefsky AS,Ehya H,Cooper HS,Provencio J,Spano AJ,Frankfurter A

更新日期：2000-04-01 00:00:00

abstract：:Primary lymphoma of the liver is rare. Recently, marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type have been described in the liver. Most of these cases occurred without known underlying liver disease, while others were seen in patients with chronic hepatitis. A case of primary hepatic MA...

journal_title：Archives of pathology & laboratory medicine

authors： Ye MQ,Suriawinata A,Black C,Min AD,Strauchen J,Thung SN

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Contamination of nontumor tissue makes genetic analysis difficult. For this reason, it is important to obtain pure tumor tissue to ensure accurate genetic analysis. OBJECTIVE:To accurately assess the incidence of mutation of tumor suppressor genes (p53: exon 5-8; APC: mutated cluster region; NF-2 gene: all ...

journal_title：Archives of pathology & laboratory medicine

authors： Sugai T,Habano W,Nakamura Si,Uesugi N,Sasou S,Itoh C

更新日期：2000-03-01 00:00:00

abstract：:Bowen disease is a variant of squamous cell carcinoma in situ. In some cases a pagetoid growth pattern can be observed with cytologically atypical clear cells arranged singly and in nests. The differential diagnosis of pagetoid Bowen disease includes primarily Paget disease and malignant melanoma in situ, as well as o...

journal_title：Archives of pathology & laboratory medicine

authors： Williamson JD,Colome MI,Sahin A,Ayala AG,Medeiros LJ

更新日期：2000-03-01 00:00:00

abstract：CONTEXT:Accurate categorization of uterine smooth muscle neoplasms by light microscopic examination is difficult. Multiple classification schemes have been proposed based on mitotic rate, nuclear atypia, and the presence or absence of necrosis. None of these classification systems has been entirely successful. Multiple...

journal_title：Archives of pathology & laboratory medicine

authors： Layfield LJ,Liu K,Dodge R,Barsky SH

更新日期：2000-02-01 00:00:00

abstract：:We describe herein a case of a mixed ductal-endocrine pancreatic carcinoma. Rare cases of mixed pancreatic tumors have been described, with endocrine and exocrine components each making up a significant proportion of the neoplasm; to our knowledge, only one case has been reported with a mixed liver metastasis. In our ...

journal_title：Archives of pathology & laboratory medicine

authors： Leteurtre E,Brami F,Kerr-Conte J,Quandalle P,Lecomte-Houcke M

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Stereotactic biopsies are increasingly being used for the diagnosis and grading of astrocytomas, and there is a growing need to obtain maximum information from these tissue samples. In everyday practice, p53 protein and Ki-67 immunohistochemical analyses are the most frequently used ancillary studies to aid i...

journal_title：Archives of pathology & laboratory medicine

authors： Tihan T,Davis R,Elowitz E,DiCostanzo D,Moll U

更新日期：2000-01-01 00:00:00

abstract：:Sarcoidlike granulomas may occur in association with Hodgkin lymphoma and non-Hodgkin lymphoma. The granulomas may be concomitant and so extensive that they obscure the malignant process. In addition, a sarcoidosis-lymphoma syndrome has been described in which there appears to be a relationship between sarcoidosis and...

journal_title：Archives of pathology & laboratory medicine

authors： Dunphy CH,Panella MJ,Grosso LE

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:This review focuses on commercial and in-house-developed reverse-transcription polymerase chain reaction (RT-PCR) assays used for the detection of enteroviral infections. In addition to providing details on the performance of RT-PCR, its specificity, and sensitivity, the clinical utility of this diagnostic me...

journal_title：Archives of pathology & laboratory medicine

authors： Romero JR

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:The apolipoprotein E alleles epsilon2 and epsilon4 have been reported as independent risk factors for coronary artery disease (CAD) and as predictors for the development of atherosclerosis. METHODS AND RESULTS:We determined by polymerase chain reaction the distribution of apolipoprotein E polymorphism in 32...

journal_title：Archives of pathology & laboratory medicine

authors： Dzimiri N,Meyer BF,Hussain SS,Basco C,Afrane B,Halees Z

更新日期：1999-12-01 00:00:00

abstract：:Inherited mutations in the genes BRCA1 and BRCA2 are associated with a significantly increased risk of breast cancer, particularly before the age of 50 years, as well as an increased risk of ovarian cancer. Patients with early-onset breast cancer or ovarian cancer at any age with a family history of either disease are...

journal_title：Archives of pathology & laboratory medicine

authors： Frank TS

更新日期：1999-11-01 00:00:00

abstract：:Public fascination with and support for genetic medicine is complicated by a deeply held fear that genetic information will be used by third parties (eg, insurers, employers, school systems) in ways that will harm the individuals from whom it was derived. Since the mid-1990s there has been much state and some federal ...

journal_title：Archives of pathology & laboratory medicine

authors： Reilly PR

更新日期：1999-11-01 00:00:00

abstract：:Ciliated hepatic foregut cysts are rare congenital lesions derived from the embryologic foregut. They are considered benign, and a review of 64 published cases revealed no instances of malignant transformation. We report a case of squamous cell carcinoma arising in a ciliated hepatic foregut cyst in a 51-year-old man....

journal_title：Archives of pathology & laboratory medicine

authors： Vick DJ,Goodman ZD,Ishak KG

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:To summarize current knowledge and recent progress pertaining to platelet concentrate preparations, modifications, and future prospects for platelet substitutes. METHODS:Current publications identified through a search of an electronic literature database were evaluated and reviewed. Relevant data were abstr...

journal_title：Archives of pathology & laboratory medicine

authors： Silberman S

更新日期：1999-10-01 00:00:00

abstract：:Hemangiopericytoma of soft tissue is a controversial pathologic entity. The relative nonspecificity of the characteristic branching capillary pattern and cytologic features of the constituent cells, in addition to the lack of a distinct immunohistochemical staining profile, has resulted in uncertainty and a lack of co...

journal_title：Archives of pathology & laboratory medicine

authors： Ceballos KM,Munk PL,Masri BA,O'Connell JX

更新日期：1999-10-01 00:00:00

abstract：INTRODUCTION:Measurement of hemoglobin A1c (HbA1c) is used as an objective measure of long-term blood glucose control in diabetic patients. Recent improvements in automation combined with new recommendations for precision and accuracy have caused us to reevaluate our methods for measuring HbA1c. OBJECTIVE:We evaluated...

journal_title：Archives of pathology & laboratory medicine

authors： Khuu HM,Robinson CA,Goolsby K,Hardy RW,Konrad RJ

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:A patented, fluid-based, thin-layer method for preparation of Papanicolaou (Pap) smears (ThinPrep Pap test) has been reported to be significantly more effective than the conventional smear invented by George Papanicolaou. We tested this position by comparing the cytologic diagnosis and specimen adequacy resu...

journal_title：Archives of pathology & laboratory medicine

authors： Díaz-Rosario LA,Kabawat SE

更新日期：1999-09-01 00:00:00

abstract：:The final decade of the last century of the second millennium ad has seen dramatic changes in all aspects of science and health care. In transfusion medicine, the blood supply is the safest it has ever been. Newer refinements and innovations are continuously being researched and implemented to achieve and further enha...

journal_title：Archives of pathology & laboratory medicine

authors： Sacher RA,Sandler SG

更新日期：1999-08-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphomas are low-grade B-cell lymphomas that occur in a variety of extranodal sites but rarely as a primary hepatic lymphoma. We describe the histological findings, immunophenotype, and immunohistochemistry of one such lymphoma found incidentally in a 69-year-old woman. The ly...

journal_title：Archives of pathology & laboratory medicine

authors： Kirk CM,Lewin D,Lazarchick J

更新日期：1999-08-01 00:00:00

abstract：:Quality improvement in blood collection centers has been a priority of regulatory and accrediting agencies for the past several years. The Food and Drug Administration and the American Association of Blood Banks have developed guidelines for quality assurance activities. Inspection programs have focused on evaluation ...

journal_title：Archives of pathology & laboratory medicine

authors： Hanson M

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:To compare the ability of the Vitek GPS-TB card with disk diffusion testing for determining the susceptibility of enterococci to vancomycin. DESIGN:Vitek susceptibility testing was performed using the GPS-TB card and software version R05.03. Disk diffusion susceptibility testing was performed according to Na...

journal_title：Archives of pathology & laboratory medicine

authors： Williams-Bouyer N,Reisner BS,Woodmansee CE,Falk PS,Mayhall CG

更新日期：1999-07-01 00:00:00

abstract：:As transfusion medicine becomes more complex, cooperative strategies are gaining increasing importance in relaying information to the treating physician and in incorporating the treating physician into the education and quality control processes. The broad domain of transfusion medicine is illustrated by the variety o...

journal_title：Archives of pathology & laboratory medicine

authors： Alving B,Alcorn K

更新日期：1999-06-01 00:00:00

abstract：:Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension. The combination diet drug phentermine-fenfluramine (or "phen-fen") was recently marketed in the United States. We describe a case of a 39-year-old woman with rapidly ...

journal_title：Archives of pathology & laboratory medicine

authors： Strother J,Fedullo P,Yi ES,Masliah E

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Metanephric adenoma is a very rare benign renal tumor; only 80 well-documented cases have been reported to date. We have seen several renal tumors that were originally incorrectly diagnosed as metanephric adenoma. DESIGN:We present 3 unusual renal tumors (2 primary and 1 metastatic), each of which illustrat...

journal_title：Archives of pathology & laboratory medicine

authors： Pins MR,Jones EC,Martul EV,Kamat BR,Umlas J,Renshaw AA

更新日期：1999-05-01 00:00:00